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The Marked Chart Wire · Health
Prostate Cancer
Johnson & Johnson said its experimental drugs pasritamig and JNJ-9401 achieved a 73 percent PSA response in a phase 1 prostate cancer study. The trial recorded no serious side effects, supporting outpatient dosing.
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CRISPR Therapeutics
CRISPR Therapeutics said 83 percent of systemic sclerosis patients reached a response target at three months with zugo-cel, while all nine myositis patients achieved moderate or major improvement.
Lupus Drug
UCB and Biogen say their lupus treatment dapirolizumab pegol achieved higher response rates than placebo in post-hoc analyses of phase 3 trial data.
Valneva
Valneva reported that its S4V2 immunization achieved its main goal in a phase 2 study, significantly lowering infection rates compared to a placebo. A separate infant study also showed positive safety data.
Mineralys Therapeutics
Mineralys Therapeutics said lorundrostat lowered systolic blood pressure by 17.8 mmHg at week 48 in a phase 3 trial extension. About 56 percent of patients reached levels below 130 mmHg.
FDA Approval
The FDA has approved daraxonrasib from Revolution Medicines for the treatment of pancreatic cancer.
Evaxion
The biotech firm disclosed new Phase 2 findings for its personalized vaccine, EVX-01. The data indicated robust immune reactions and validated its AI-Immunology platform.
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